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Biochem_Student

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Lepton

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  1. Hello Folks, I'm a Biochemistry student trying to do some extra work over the summer and to get ahead in my next year at university. I've been doing some problems/questions based on what is available for download at my university intranet site/black board. One of the practice questions has me stumped and I hoped to ask for some help if at all possible? The whole point of the exercise is to calculate the maximum realizable ATP yield per mole of myristic acid being fully oxidized to CO2 and H2O in a skeletal muscle cell under aerobic conditions. I'm trying to understand the step-by-step calculation so as to compare to other substrates such as glucose if that makes sense? I've never really done anything like this before and Biochemistry isn't my field (I'm more animals, plants and ecology). So far what I know is that Myristoyl CoA is the product of the activation of myristic acid (C14:0) in the cytoplasm of a cell with a low energy charge, prior to transport to the mitochondria for beta-oxidation. The overall reaction of beta-oxidation of myristoyl CoA in the mitochondrial matrix of an animal cell is: 6 FAD + 6 NAD+ + 6 CoASH + 6 H2O + H(CH2CH2)6CH2CO-SCoA --> 7 CH3CO-SCoA + 6 FADH2 + 6 NADH + 6 H+
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