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(Context) I'm a medical student in the UK about to apply for an intercalated year of academic research before my clinical training starts. Anyway, I was considering a project based on the changes to mitochondria during exercise. There are papers that have been published showing certain genes in the nuclear genome are upregulated during exercise and aerobic training will lead to an increased mitochondrial count in each cell. I am wondering if there is any published research as to whether or not there is an increase in transcription in the mitochondrial genome in response to exercise. It would make sense that as well as increasing the number of mitochondria in a muscle cell, there would also be more respiratory proteins in each mitochondrion, leading to a more efficient mitochondrion. As the mitochondrial genome codes some of these proteins, it follows that those genes would be upregulated. I can't find any research on the subject, would anyone know of any? Cheers