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Amino acid nasty titration question


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#1 thankududes

thankududes

    Lepton

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Posted 26 October 2016 - 01:53 AM

Hey, if I start a titration of Histidine at the pKa of the N-terminus (pH of 9.1) with HCl, where would the first equivalence point be? I was thinking that the 1st equivalence point would be between 9.1 and 6.0 (pI) however mols of acid would not equal mols of base until the pka of 6.0 is reached. On the titration curve I must label where this equivalence point is but I have never started a titration at a pka before, can someone please help? thank you!


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