blazinfury Posted December 14, 2014 Share Posted December 14, 2014 I understand the idea of how anergy happens but I cannot find a clear explanation for why it happens and why there is no co-stimulation? What regulatory mechanism is preventing the B7 and CD28 receptors from interacting? I ask because at least in the thymus, the T cells are in an isolated and controlled environment and they have a hard time leaving if they have receptors against self. However, the peripheral tissues are like an open area. So what is the regulation that is occurring there? Link to comment Share on other sites More sharing options...
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