Replicated strands, 1 more error prone?

[Redrang604]

okay, in replication one strand is replicated continuously and the other is discontinuous due to nucleotides can only be attached in one direction, so one side has to constantly start and stop (i know this has a specific term related to it) does this make the discontinuosly replicated strand more error prone because the polymerase has to constantly re orient itself?

[ecoli]

I've never heard any evidence towards this. The lagging strand (the discontinued replicated strand, made by okazaki fragments) will replicate slower then the leading strand. I would think nucleases and polymerases identify and correct most mistakes.

[Redrang604]

okazaki, that's it. Only asking because it reorients itself each time using like a three base series, could it restart in the wrong spot?

[ecoli]

Could what restart in the wrong spot? I think you mean polymerase, but could you clarify?

[Redrang604]

yes i mean the polymerase, each okazaki fragment starts at a certain point, could this be more error prone than the other strand having only one start point.

[ecoli]

Like I said before, I haven't heard of this happening. Your body is pretty good at fixing polymerase mistakes. Also, becasue the lagging strand is slower, I think this might cause less chance of error. But, I don't know for sure.