wildcat Posted April 22, 2010 Share Posted April 22, 2010 Hey everyone, I had a question about the a part of the endocrine system, particularly the hormones called the chatecholamines. If the chatecholamines (epinephrine, norepinehprine and dopamine) are synthesized by modifying tyrosine, would a person with a metabolic disorder like albinoism (a tyrosinase deficiency)have a reduced fight-or-flight response when put in a stressful situation? I know that tyrosinase is an enzyme (otherwise, it wouldn't have the suffix -ase), but would that have any effect on the sympathetic nervous system? Thanks Link to comment Share on other sites More sharing options...
Greippi Posted April 22, 2010 Share Posted April 22, 2010 Adrenaline (ephinephrine) can also be synthesised from phenylalanine, so I assume if there was a problem with converting tyrosine to adrenaline, phenylalanine would just be used instead. HOWEVER: In the adrenaline synthesis pathway, tyrosine is oxidised using tyrosine hydroxylase, not tyrosinase. Link to comment Share on other sites More sharing options...
psynapse Posted April 25, 2010 Share Posted April 25, 2010 A person with albinism will not have an affected fight or flight response. The reason is tyrosinase converts tyrosine to melanin a pigment compound. Tyrosine Hydroxylase a different enzyme is responsible for converting tyrosine into L-Dopa and subsequently the catecholamines. Link to comment Share on other sites More sharing options...
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