Jump to content

The catecholamines

Recommended Posts

Hey everyone,


I had a question about the a part of the endocrine system, particularly the hormones called the chatecholamines.


If the chatecholamines (epinephrine, norepinehprine and dopamine) are synthesized by modifying tyrosine, would a person

with a metabolic disorder like albinoism (a tyrosinase deficiency)have a reduced fight-or-flight response when put in a stressful situation?


I know that tyrosinase is an enzyme (otherwise, it wouldn't have the suffix -ase), but would that have any effect on the sympathetic nervous system?



Link to comment
Share on other sites

Adrenaline (ephinephrine) can also be synthesised from phenylalanine, so I assume if there was a problem with converting tyrosine to adrenaline, phenylalanine would just be used instead.




In the adrenaline synthesis pathway, tyrosine is oxidised using tyrosine hydroxylase, not tyrosinase.

Link to comment
Share on other sites

A person with albinism will not have an affected fight or flight response. The reason is tyrosinase converts tyrosine to melanin a pigment compound.


Tyrosine Hydroxylase a different enzyme is responsible for converting tyrosine into L-Dopa and subsequently the catecholamines.

Link to comment
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now
  • Create New...

Important Information

We have placed cookies on your device to help make this website better. You can adjust your cookie settings, otherwise we'll assume you're okay to continue.