ponybn Posted February 1, 2010 Share Posted February 1, 2010 hi... i wanted to know whether it is possible to produce acacetin by chemical means, also how feasible is the process and how economical is it?? Am planning for a project and desperately need the information...... please help.......... Link to comment Share on other sites More sharing options...
Horza2002 Posted February 2, 2010 Share Posted February 2, 2010 Ive just had a quick look at the problem and this was just the first one i came up with. All the steps are a well known as are the starting materials so it shoud work ok then. The second step is a 6-endo0DIG cyclisation which might be a little slow but should be ok. Link to comment Share on other sites More sharing options...
akcapr Posted February 3, 2010 Share Posted February 3, 2010 in that synth the grignard adds to the double bond.. but then why is it still there in the product shouldnt it be gone by that approach Link to comment Share on other sites More sharing options...
Horza2002 Posted February 4, 2010 Share Posted February 4, 2010 (edited) Arrr yes very good point.... lol yep i forgot that you don't get the double bond back.....let me have a rethink! Merged post follows: Consecutive posts mergedDraw the curly arrows from the deproataned amine. You'll find that meta is the only position it wont get into the nitro Merged post follows: Consecutive posts mergedSorry ignore that bit about curly arrows and nitro groups Edited February 3, 2010 by Horza2002 Link to comment Share on other sites More sharing options...
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