-Demosthenes- Posted April 7, 2004 Share Posted April 7, 2004 Alcohol is the only drug that we've mentioned that is pysically addicting. This makes it very dangerous, making the user physically sick if they don't consume it. Link to comment Share on other sites More sharing options...
fafalone Posted April 7, 2004 Share Posted April 7, 2004 The LD50 in humans is about 1400mg/kg.. this works out to be around BAL 0.42%, or about 20 shots of 80 proof alcohol. But I'm comparing this to marijuana, which has a lethal dose so high it's never been reported. Link to comment Share on other sites More sharing options...
Crash Posted April 7, 2004 Share Posted April 7, 2004 Hey wolfson can you explain that last bit? And faf where you hear that cannibis is safer than cigarettes? Link to comment Share on other sites More sharing options...
wolfson Posted April 7, 2004 Share Posted April 7, 2004 CH = cerebral hyperactivity, similar to the contusions seen in the prefrontal cortex on an alcoholics brain. Whereas the Hippocampus is near to the amygdala, and the pituitary galnd. Hoped that helped you. Link to comment Share on other sites More sharing options...
Crash Posted April 8, 2004 Share Posted April 8, 2004 Is there a lethal limit to cigarettes? i heard that nicotine is quite lethal in small amounts Link to comment Share on other sites More sharing options...
fafalone Posted April 8, 2004 Share Posted April 8, 2004 THe LD50 is 60mg; but theres no more than 3-4mg that reaches the smoker per cigarette, and its metabolized quickly. Take 20 of the nicotine gums and chew them all at once tho... you'll probably die. Link to comment Share on other sites More sharing options...
NSX Posted April 8, 2004 Share Posted April 8, 2004 THe LD50 is 60mg; but theres no more than 3-4mg that reaches the smoker per cigarette, and its metabolized quickly. Take 20 of the nicotine gums and chew them all at once tho... you'll probably die. LD50? Is LD = Lethal Dosage? What is 50 for? & what about those who chew tobacco? Isn't that bad then? Link to comment Share on other sites More sharing options...
fafalone Posted April 8, 2004 Share Posted April 8, 2004 The 50 means its lethal in 50% of subjects at that dose. Link to comment Share on other sites More sharing options...
-Demosthenes- Posted May 1, 2004 Share Posted May 1, 2004 Is there a lethal limit to cigarettes? i heard that nicotine is quite lethal in small amounts I know this guy who used to buy chewing tobacco and make it into a liquid (I don't remember how) then he would spay it on his garden to kill the bugs! I'm thinking it's pretty poisnous. Link to comment Share on other sites More sharing options...
alt_f13 Posted May 1, 2004 Share Posted May 1, 2004 I know this guy who used to buy chewing tobacco and make it into a liquid (I don't remember how) then he would spay it on his garden to kill the bugs! I'm thinking it's pretty poisnous. His celery had a half life of 2 months within the body. Anyone have a chart of the LD50 for many different drugs? Something very interesting to see. Link to comment Share on other sites More sharing options...
Guest hypnosonance Posted May 17, 2004 Share Posted May 17, 2004 << "" http://www.druglibrary.org/crl/neur...20JNeurosci.pdf If you laugh at the Journal of Neuroscience, I laugh at your cretinism. "" >> There is only one sentence in this entire study that needs to be read, and it's this one, written near the end: "Although there is no evidence that marijuana is neurotoxic for the human brain," What comes before and after is moot. This study was conducted on rats, not humans. Link to comment Share on other sites More sharing options...
fafalone Posted May 17, 2004 Share Posted May 17, 2004 ...because animal studies are done just for the hell of it, they have no application to human medicine. Please refrain from commenting on basic axioms of research progression when you clearly don't understand the whole point of testing on rats. Link to comment Share on other sites More sharing options...
Guest hypnosonance Posted May 17, 2004 Share Posted May 17, 2004 <<...because animal studies are done just for the hell of it, they have no application to human medicine.>> That's not my opinion and I said nothing to infer it was. The evolution of human medicine wasn't the topic of this thread. <<Please refrain from commenting on basic axioms of research progression when you clearly don't understand the whole point of testing on rats.>> I understand the point of testing on rats. What I don't understand is why we are discussing the application and residual benefits of rat testing when the true point of my post was to debunk your initial post. You stated: "Wrong. Marijuana has demonstrated neurotoxicity to cells in the hippocampus, resulting in memory loss." You failed to mention rats here. I simply pointed that out. I'm not questioning the validity of animal testing in science. I'm pointing out that your statement is erroneous. The original poster wasn't wrong, but it turns out you are. In the future, I'll try to have my basic axioms in better order. Apologies. Link to comment Share on other sites More sharing options...
fafalone Posted May 17, 2004 Share Posted May 17, 2004 It's not erroneous, because there's more reason to believe it's not a random interaction with some protein unique to rats than to believe that to be the case. Link to comment Share on other sites More sharing options...
BrainMan Posted May 20, 2004 Share Posted May 20, 2004 fafalone- The statement might be erroneous for a few reasons: 1) It is based upon animal testing (as mentioned), 2) Most of the citations given are administering very large amounts of marijuana to rats over long periods of time (three and six months), which is probably unrealistic compared to normal, average human use, 3) marijuana use may lead to both memory loss and cell death, but no direct connection between the two is established, which goes to point 4) there may be many other factors involved in the memory problems having little to nothing to do with the cell death. The memory problems due to marijuana use in humans is not permanent. Is memory recoved to due the cells recovering? New cells growing? Older cells taking over functioning? Something having nothing to do with cell loss? Does the cell loss matter in the long term at all? I dont know, the authors of this study dont know, and I suspect that you dont know either... hence the erroneous statement. Hypnosonance- If you are going to critique a study, at least take the time to do it right. Link to comment Share on other sites More sharing options...
aommaster Posted May 20, 2004 Share Posted May 20, 2004 Well, what have you guys decided? Does it kill or not? Or haven't you? Link to comment Share on other sites More sharing options...
alt_f13 Posted May 25, 2004 Share Posted May 25, 2004 I don't think so. But then again... I think I used to. [edit] Or was it the other way around? Link to comment Share on other sites More sharing options...
Guest guyoncoach Posted May 25, 2004 Share Posted May 25, 2004 i smoke marijuana just about every weekend a few joints. On monday i feel a little light headed and slow but by tuesday i feel completely normal, thinking quickly and logically. Link to comment Share on other sites More sharing options...
Guest zephyr Posted May 30, 2004 Share Posted May 30, 2004 Marijuana does NOT kill brain cells.I've speculated about this a lot... and then decided to read up to decide. It is not addictive when done in moderation. Anyway. For those in doubt, do check out this site at least.... http://paranoia.lycaeum.org/marijuana/facts/mj-health-mythology I have links to several other sites that may help you take away your doubts. But always do remember: USE it, dont abuse it. Control the weed, dont let it control you. That's when it is the most fun. And the most safe.... Link to comment Share on other sites More sharing options...
admiral_ju00 Posted May 31, 2004 Share Posted May 31, 2004 Effects on the Brain Scientists have learned a great deal about how THC acts in the brain to produce its many effects. When someone smokes marijuana, THC rapidly passes from the lungs into the bloodstream, which carries the chemical to organs throughout the body, including the brain. In the brain, THC connects to specific sites called cannabinoid receptors on nerve cells and influences the activity of those cells. Some brain areas have many cannabinoid receptors; others have few or none. Many cannabinoid receptors are found in the parts of the brain that influence pleasure, memory, thought, concentration, sensory and time perception, and coordinated movement(5). The short-term effects of marijuana can include problems with memory and learning; distorted perception; difficulty in thinking and problem solving; loss of coordination; and increased heart rate. Research findings for long-term marijuana use indicate some changes in the brain similar to those seen after long-term use of other major drugs of abuse. For example, cannabinoid (THC or synthetic forms of THC) withdrawal in chronically exposed animals leads to an increase in the activation of the stress-response system(6) and changes in the activity of nerve cells containing dopamine(7). Dopamine neurons are involved in the regulation of motivation and reward, and are directly or indirectly affected by all drugs of abuse. and Effects of Heavy Marijuana Use on Learning and Social Behavior Depression(19), anxiety(20), and personality disturbances(21) have been associated with marijuana use. Research clearly demonstrates that marijuana has potential to cause problems in daily life or make a person’s existing problems worse. Because marijuana compromises the ability to learn and remember information, the more a person uses marijuana the more he or she is likely to fall behind in accumulating intellectual, job, or social skills. Moreover, research has shown that marijuana’s adverse impact on memory and learning can last for days or weeks after the acute effects of the drug wear off(22, 23). Students who smoke marijuana get lower grades and are less likely to graduate from high school, compared with their non-smoking peers(24, 25, 26, 27). A study of 129 college students found that, for heavy users of marijuana (those who smoked the drug at least 27 of the preceding 30 days), critical skills related to attention, memory, and learning were significantly impaired even after they had not used the drug for at least 24 hours(28). The heavy marijuana users in the study had more trouble sustaining and shifting their attention and in registering, organizing, and using information than did the study participants who had used marijuana no more than 3 of the previous 30 days. As a result, someone who smokes marijuana every day may be functioning at a reduced intellectual level all of the time. More recently, the same researchers showed that the ability of a group of long-term heavy marijuana users to recall words from a list remained impaired for a week after quitting, but returned to normal within 4 weeks(29). Thus, it is possible that some cognitive abilities may be restored in individuals who quit smoking marijuana, even after long-term heavy use. Workers who smoke marijuana are more likely than their coworkers to have problems on the job. Several studies associate workers’ marijuana smoking with increased absences, tardiness, accidents, workers’ compensation claims, and job turnover. A study of municipal workers found that those who used marijuana on or off the job reported more “withdrawal behaviors”—such as leaving work without permission, daydreaming, spending work time on personal matters, and shirking tasks—that adversely affect productivity and morale(30). In another study, marijuana users reported that use of the drug impaired several important measures of life achievement including cognitive abilities, career status, social life, and physical and mental health(31). http://www.nida.nih.gov/Infofax/marijuana.html so the direct answer to the question is: NO however it does screws with the receptors and ionic regulation/passages. Link to comment Share on other sites More sharing options...
[Tycho?] Posted June 6, 2004 Share Posted June 6, 2004 I have read on this a good amount, and no, it does not. It coats braincells with a fatty substance, causing them to stop working. But in 20-30 days or so, the fat wears off, and the cells can continue to work normally. So when using pot, brain cells will get coated and become usless, but as long as you stop, and stay stopped for about a month, you should technically be fine. Technically because if you are a heavy user you may have developed bad habits, because of it. Link to comment Share on other sites More sharing options...
budullewraagh Posted June 22, 2004 Share Posted June 22, 2004 tetrahydrocannabinol is extremely insoluble in H2O: only 0.28 g/100 mL at 23 C C21H30O2. it is an ether, an alcohol and has a cyclohexane group. http://chemfinder.cambridgesoft.com/ChemIndex/ChemIndex/ChemIndex_action.asp?formgroup=base_form_group&dbname=ChemIndex&dataaction=Get_structure&Table=MolTable&Field=MOL_ID&DisplayType=sizedgif&width=225&height=200&StrucID=2153 ^structural image it's interesting. anybody know the exact reactions THC has? EDIT: SW00T I AM AN ATOM! Link to comment Share on other sites More sharing options...
Guest Kakashi420 Posted August 16, 2004 Share Posted August 16, 2004 Im trying to email Tycho? right now in case he no longer responds to this subject, but I'm very interested in the fatty coating theory, it sounds very plausible and am anxious to use it in an argument. Link to comment Share on other sites More sharing options...
[Tycho?] Posted August 29, 2004 Share Posted August 29, 2004 Im trying to email Tycho? right now in case he no longer responds to this subject, but I'm very interested in the fatty coating theory, it sounds very plausible and am anxious to use it in an argument. I read this before, but it was a long time ago and I dont remember when. I will try and find a source for you. Link to comment Share on other sites More sharing options...
[Tycho?] Posted August 29, 2004 Share Posted August 29, 2004 Well, as you can imagine, it is very difficult to find non-biased information on this subject. There are numerous sources that say it does not indeed kill braincells, however I have been unable to find anything corroborating my earlier statement. I will continue to look, in the meantime: MYTH: MARIJUANA KILLS BRAIN CELLS. Used over time, marijuana permanently alters brain structure and function, causing memory loss, cognitive impairment, personality deterioration, and reduced productivity. FACT: None of the medical tests currently used to detect brain damage in humans have found harm from marijuana, even from long term high-dose use. An early study reported brain damage in rhesus monkeys after six months exposure to high concentrations of marijuana smoke. In a recent, more carefully conducted study, researchers found no evidence of brain abnormality in monkeys that were forced to inhale the equivalent of four to five marijuana cigarettes every day for a year. The claim that marijuana kills brain cells is based on a speculative report dating back a quarter of a century that has never been supported by any scientific study. http://www.lindesmith.org/marijuana/factsmyths/ Also, a canadian senate comittee did extensive research on the subject. A summery of their report can be found here: http://www.parl.gc.ca/37/1/parlbus/commbus/senate/com-e/ille-e/rep-e/summary-e.pdf Its kinda long, but there is extremely useful information in there, from a pretty darned reputable source. Link to comment Share on other sites More sharing options...
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