alexproton Posted January 26, 2007 Share Posted January 26, 2007 In a recent research they found that although silent mutations dont change the amino acids in the polypeptide chain they can harm its function... so then there is something more between the protein and the DNA.... somethin that we definitely dont know... Link to comment Share on other sites More sharing options...
Phi for All Posted January 26, 2007 Share Posted January 26, 2007 Can you provide a link to the research or give us a direction for further comment? What do you think the "something more" might be? Link to comment Share on other sites More sharing options...
Bluenoise Posted January 27, 2007 Share Posted January 27, 2007 Hmmm I kinda doubt this. And I'm an RNA/DNA guy... I can see how there might be some promoter elements present within the coding region, that maybe disrupted and result lower protein expression. But that's not really harming function. Link to comment Share on other sites More sharing options...
alexproton Posted January 27, 2007 Author Share Posted January 27, 2007 I found that reaseearch result in "nature"....http://www.nature.com Link to comment Share on other sites More sharing options...
Bluenoise Posted January 27, 2007 Share Posted January 27, 2007 I think you're going to have to be more specific than that. Can you find a link to a paper? or article at least? (To mean it sounds like you're missinterpreting the recently discovered histone code...) Link to comment Share on other sites More sharing options...
CharonY Posted January 31, 2007 Share Posted January 31, 2007 I think he is referring to effects of the sequence on, say splicing, mRNA transport or translation. One example that I know of and which is quite intuitively understandable is for instance a silent mutation changes to a rarely used codon (but leading to the same AA). So if the given tRNA is less abundant in the cell, the translation is slowed down apparently leading to a different, less efficient conformation. This has been demonstrated for the MDR1 gene, for instance. (Kimchi-Safarty, Science 2006). Link to comment Share on other sites More sharing options...
Bluenoise Posted January 31, 2007 Share Posted January 31, 2007 ^^ He's so unspecific that your guess is just as good as anyone elses. Link to comment Share on other sites More sharing options...
CharonY Posted February 1, 2007 Share Posted February 1, 2007 Good point. Actually funny how the focus of one's own work influences the interpretation, though (I am more of an RNA/Protein guy...). Link to comment Share on other sites More sharing options...
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