Jump to content

Tissue typing


Recommended Posts

A couple of HLA related questions:

 

1. Why is HLA matching not so important in kidney transplantation, but critically important in stem cell transplantation?

 

2. Kidney transplant tissue typing refers to the HLA-DR antigen whereas stem cell transplant tissue typing refers to the HLA-DRB1 antigen. Is there any difference between "DR" and "DRB1"?

 

Cheers!

Link to comment
Share on other sites

Well, HLA matching is critically important for stem cell transplants since the stem cells are essentially going to remake all of the circulating immune cells in your body. If the MHCs are different in the transplanted cells than the host tissue cells, you're going to possibly develop autoreactive T and B cells (donor or host), leading to either GVHD or graft rejection. That's why stem cell recipients are usually immunosuppressed, since the donor stem cells will almost certainly not be a perfect match.

 

I think that HLA-DR encompasses HLA-DRA and HLA-DRB.

Link to comment
Share on other sites

zyncod - thank you very much for your informative answers.

 

j_p - stem cells aren't so much part of my life as part of my Ph.D. studies at the moment! As is kidney transplantation. And I can't find the answers to my questions on Google.

Link to comment
Share on other sites

Ahh, that is a good thing.

 

Thank you for the work you are doing and may do in the future. There will be a lot of people depending on you.

 

So, ah, maybe you should stop goofing off on message boards and get back to work?

 

:)

Link to comment
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now
 Share

×
×
  • Create New...

Important Information

We have placed cookies on your device to help make this website better. You can adjust your cookie settings, otherwise we'll assume you're okay to continue.