matus Posted October 8, 2022 Share Posted October 8, 2022 Heavy metals are useful industrially, and omnipresent- however, as cumulative toxins with low (or no) safe dose, that is a bit of a problem; so I was wondering: mammals (and most life on earth) already deal with "toxic heavy metals"- Fe, Cu, Mn... by producing proteins (eg ferritin) that bind it before it has a chance to break anything too important. Here comes the question then: would it be possible to create a gene therapy to produce low, but constant levels of heavy metal (at least some of them- Hg, Pb, Pt) chelating agents in the blood? An antibody, or a cysteine-rich oilgopeptide or something specific enough not to chelate away the useful stuff (it seems dimercaprol ignores biogenic transition metals, so perhaps a biological analogue?) to be secreted by a random cell type into the blood and grant one passive immunity to low to medium doses of the most prevalent (and problematic) heavy metals? Link to comment Share on other sites More sharing options...
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