Ciak Posted February 1, 2021 Share Posted February 1, 2021 If I have 3o amine on a side chain, and I want to make it 2o amine by getting rid of -CH3, can I use BrCN and KOH ? Is this correct? Link to comment Share on other sites More sharing options...
chenbeier Posted February 1, 2021 Share Posted February 1, 2021 This is the "von Braun reaction". But this substitutes one alkyl to nitril. How do you know that methyl and not the R will be substitutet. The nitril has to be treated further. Nitril to Carbamidacid Link to comment Share on other sites More sharing options...
Ciak Posted February 1, 2021 Author Share Posted February 1, 2021 this is the fluoxetine synthesis and the von Braun reaction at the last step. I wanted to know if I can use this method to other synthesis too Link to comment Share on other sites More sharing options...
chenbeier Posted February 1, 2021 Share Posted February 1, 2021 Probably. Link to comment Share on other sites More sharing options...
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