Niklas Posted September 29, 2019 Share Posted September 29, 2019 I’m currently studying about collagen. And i have a couple of questions i can’t find in the litteraturen. I’m sorry for my Eng, it’s not my nativ language. I understand that the H-Bonds betwine Alfa-strands in tropocollanin occurs with hydroxyproline, but to what Other aminoacid does it connect to? Is it betwine another hydroxyproline in the next strand ? is the h-Bonds betwine tropocollagen aswell? Or is it only allysin- lysine covalent bonding? what happens with the bonds when the cell gets Old? Does it increase or decrease? My guess is that the more interaction the more bonding occurs, thats why old ”meat” gets so chewy. ? Or? Link to comment Share on other sites More sharing options...
studiot Posted September 29, 2019 Share Posted September 29, 2019 Does this help? You will find the hydrogen bond description near the end of the collagen article on the second attachment. Link to comment Share on other sites More sharing options...
studiot Posted September 29, 2019 Share Posted September 29, 2019 Revised second page Link to comment Share on other sites More sharing options...
Niklas Posted September 29, 2019 Author Share Posted September 29, 2019 Awsome, it sais that glycine is a proton donor and the accepter is the CO group of hydroxyproline. what bok is that? ’it has alot of information that our book left out. Thank for the help. Link to comment Share on other sites More sharing options...
studiot Posted September 29, 2019 Share Posted September 29, 2019 (edited) 39 minutes ago, Niklas said: Awsome, it sais that glycine is a proton donor and the accepter is the CO group of hydroxyproline. what bok is that? ’it has alot of information that our book left out. Thank for the help. Stryer https://www.google.co.uk/search?source=hp&ei=-veQXYC_Goyua-TslrgG&q=stryer+biochemistry&oq=stryer+&gs_l=psy-ab.1.0.0j0i7i30l2j0l3j0i7i10i30j0i10j0l2.238.7244..10416...0.0..0.178.800.5j3......0....1..gws-wiz.......0i131.hPo-QpUYwIA I'm suprised your text has less, Stryer is good but not specifically medical. This one has a great deal more detail about collagen. https://www.amazon.com/Biochemistry-Concise-Text-Medical-Students/dp/0702014443 Edited September 29, 2019 by studiot Link to comment Share on other sites More sharing options...
BabcockHall Posted September 30, 2019 Share Posted September 30, 2019 It has been a long time since I looked into this; however, I am under the impression that the hydroxyproline residues, the hydroxyl groups on the side-chains form hydrogen bonds to water. For whatever reason the presence of hydroxyproline residues increases the thermal stability of collagen. Link to comment Share on other sites More sharing options...
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