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Marry someone born to consanguineous couple?

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I am dating someone who was born to a consanguineous couple (his father married his niece). I am completely unrelated to him. If we get married, will our children have elevated risks for any birth defects because of his parents' consanguinity?

Also, note that he had a younger brother who passed away. He had a mental disease since birth.

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I think it would be a small , very small likelihood of that . Not impossible , but most likely unlikely .

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