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How to find protein information?


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There are several databases that can assist you in that, though of course without actual experimental verification they all will just be predictions based on sequence similarities. Uniprot is a general database that aggregates a lot of this information. If you want to implement something yourself you can look into protein family/domain databases such as pfam, prosite, etc.

But again, usually you would knock out the whole domain, or at least a sizeable chunk of it. Figuring out the required minimum mutation to deactivate a given activity is quite a bit trickier.

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There are several databases that can assist you in that, though of course without actual experimental verification they all will just be predictions based on sequence similarities. Uniprot is a general database that aggregates a lot of this information. If you want to implement something yourself you can look into protein family/domain databases such as pfam, prosite, etc.

But again, usually you would knock out the whole domain, or at least a sizeable chunk of it. Figuring out the required minimum mutation to deactivate a given activity is quite a bit trickier.

Thanks for your reply

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