BiomedbabeUK Posted December 18, 2016 Share Posted December 18, 2016 What do you think are the pros and cons to three parent babies and what are some common mitochrondrial diseases (other than Leigh syndrome)? Link to comment Share on other sites More sharing options...
Daecon Posted December 19, 2016 Share Posted December 19, 2016 I think "three parent" is a bit of a misnomer, it's just a surrogate egg. Link to comment Share on other sites More sharing options...
Strange Posted December 19, 2016 Share Posted December 19, 2016 I think "three parent" is a bit of a misnomer, it's just a surrogate egg. That is a good description. I am also unhappy with the common description "DNA from three people". While strictly true, it is quite misleading. After all, you could say the same about someone who has had an organ transplant. Link to comment Share on other sites More sharing options...
StringJunky Posted December 19, 2016 Share Posted December 19, 2016 (edited) That is a good description. I am also unhappy with the common description "DNA from three people". While strictly true, it is quite misleading. After all, you could say the same about someone who has had an organ transplant. But the mitochondria is heritable, an organ transplant is not. Edited December 19, 2016 by StringJunky Link to comment Share on other sites More sharing options...
Endy0816 Posted December 19, 2016 Share Posted December 19, 2016 I'm concerned that suggests a three-way mixing of Nuclear DNA. Link to comment Share on other sites More sharing options...
StringJunky Posted December 19, 2016 Share Posted December 19, 2016 (edited) I'm concerned that suggests a three-way mixing of Nuclear DNA. Well, mitochondria are pretty vital and in every cell in a person. There is two strands of heritability and that third person is providing the other strand. Edited December 19, 2016 by StringJunky Link to comment Share on other sites More sharing options...
Strange Posted December 19, 2016 Share Posted December 19, 2016 But the mitochondria is heritable, an organ transplant is not. Touche! Well, mitochondria are pretty vital and in every cell in a person. There is two strands of heritability and that third person is providing the other strand. Two "strands" might be a poor choice of word, in this context ... 1 Link to comment Share on other sites More sharing options...
StringJunky Posted December 19, 2016 Share Posted December 19, 2016 (edited) Touche! Two "strands" might be a poor choice of word, in this context ... Touche to you! Three strands; mitochondria has RNA.. Or, Should that be 2+2+1 strand. Yeah, it is an ambiguous word here. Seriously, I find this one a bit fuzzy whether the person providing the egg is or not. Either way, I imagine it's a big deal on the woman providing the egg and allowing it's use; it's not like they can just '"whip it out'" a la men. I suppose, as men, we could hypothetically imagine that mitochondrial RNA inheritance is passed on by the male in his sperm. What do you think in this context: is the resulting baby part of you? Would you feel an investment in that process? You are helping to make that baby because without you they will not reach their full physiological potential and your effort will be passed on to their children and so on... Edited December 19, 2016 by StringJunky Link to comment Share on other sites More sharing options...
Delta1212 Posted December 19, 2016 Share Posted December 19, 2016 Touche to you! Three strands; mitochondria has RNA.. Or, Should that be 2+2+1 strand. Yeah, it is an ambiguous word here. Seriously, I find this one a bit fuzzy whether the person providing the egg is or not. Either way, I imagine it's a big deal on the woman providing the egg and allowing it's use; it's not like they can just '"whip it out'" a la men. I suppose, as men, we could hypothetically imagine that mitochondrial RNA inheritance is passed on by the male in his sperm. What do you think in this context: is the resulting baby part of you? Would you feel an investment in that process? You are helping to make that baby because without you they will not reach their full physiological potential and your effort will be passed on to their children and so on... If you could donate blood and have a single gene extracted from the DNA in that blood and spliced into the genetic code of a zygote that had a genetic defect, how would you feel towards the resultant child? Link to comment Share on other sites More sharing options...
StringJunky Posted December 20, 2016 Share Posted December 20, 2016 If you could donate blood and have a single gene extracted from the DNA in that blood and spliced into the genetic code of a zygote that had a genetic defect, how would you feel towards the resultant child? It would be 1/20 000 mine in quantitative terms. Where does one draw the line. Link to comment Share on other sites More sharing options...
Delta1212 Posted December 20, 2016 Share Posted December 20, 2016 It would be 1/20 000 mine in quantitative terms. Where does one draw the line. Actually, that got me thinking about this in a good way. Mitochondrial DNA is passed down through the female line. The person donating the mitochondrial DNA would be as related to the child as some distant cousin descended through the female line so many generations back that they share no other DNA. That's the approximate DNA-level relationship that they would share. 1 Link to comment Share on other sites More sharing options...
jimmydasaint Posted January 2, 2017 Share Posted January 2, 2017 Actually, that got me thinking about this in a good way. Mitochondrial DNA is passed down through the female line. The person donating the mitochondrial DNA would be as related to the child as some distant cousin descended through the female line so many generations back that they share no other DNA. That's the approximate DNA-level relationship that they would share. There is a very rare case of paternal mitochondrial inheritance. Whilst extremely rare, it also calls into question some of the hypotheses of evolutionary biologist that depend upon exclusively maternal inheritance of mitochondria. The researchers think inheritance of paternal mitochondrial DNA is probably very rare. But the findings will have implications for a number of branches of biology. Evolutionary biologists often date the divergence of species by the differences in genetic sequences in mitochondrial DNA. Even if paternal DNA is inherited very rarely, it could invalidate many of their findings. It will also have implications for scientists investigating inherited metabolic diseases. https://www.newscientist.com/article/dn2716-mitochondria-can-be-inherited-from-both-parents/ Link to comment Share on other sites More sharing options...
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