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CharonY

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Everything posted by CharonY

  1. That is a crucial point (which I conveniently and to my shame overlooked). But on the other aspects, yes development of complex traits are also regulated by quantitative balances of the various players (including transcriptome, proteome and metabolome). The balance of many of these constituents is what results in certain cellular and tissue phenotypes and not only the types of proteins present (though that is an important point, too, of course).
  2. I am not terribly sure. I was under the impression that in many countries, including US the separation was to protect individual practitioners from state persecution. An offspring of freedom of thoughts, so to say. The exception would be laicite (pardon my lack of accents) adopted by France and Turkey which distinctly calls to lessen the influence of church on public institutions. Though with the general rise of secularism the quoted part may be the current de facto (if not the historical) reason.
  3. Sounds like a organization and time management could be your issue. A few starters: - Use a time management system or optimize the system you have got. - Establish standard methods and workflows, document and organize them well. The goal is just to blindly down a workflow and end up with results without having to twiddle on things too much. Standardization will free up your mind as you can do things without having to think (and forget) about them. - Look at your time management system, and put in the times when you run things. Develop the discipline to follow those time tables. If you do not manage to keep up, use your time table ti figure out where you screw up and adjust accordingly - put in realistic expectations for time (figure in time to do analysis, write report, meetings etc.) see how it matches up with real work and figure out the bottlenecks. - if you are forgetful, document everything. If you are better using your hands I recommend a notepad and pen on your body at all times. These are the equivalent of a utility knife - In addition, set up a routine for everything as much as you can. E.g. plan ahead for weekly/monthly things like calibration maintenance and define regular times per day. Example, come in, start up instruments, load samples, program run, coffee/follow up paperwork and email, analyze data, lunch, start up next run, write report, etc.
  4. Keep us in the loop how it went. If we had more people it would be interesting to discuss the different types of grants and grant mechanisms. I have been in a few countries by now and it is interesting to see how the different granting agencies are driven by research culture, politics and funding sources...
  5. OK, you are cherry-picking data now. These kind of comparisons yield little to no information and just emphasize bias. For example, Switzerland only allowed women to vote on the Federal level in 1971. That is over 50 years after the US. One Canton )(Appenzell Innerrhoden) only allowed women to vote locally 1991. Using OPs approach it is clear that Switzerland is one of the most misogynist nations on Earth, only eclipsed by Nations like Qatar, Oman, Kuwait and the Arab Emirates (Egypt had it in 1956, Turkey 1930, Iran 1963 ). One thing of note is that I have never heard anyone stating that the US is the "most democratic", rather they tend to be proud of their liberties (whether justified or not is probably another matters).
  6. Regions characterized as non-coding can still harbor unidentified sRNA or, more commonly have a regulatory role (e.g. as transcription factor binding sites). In fact, many (most) cases SNPs exert their effects due to regulatory changes rather than actual mutations in protein-coding regions themselves.
  7. In addition to the points mentioned by others I wanted to emphasize that mercury as preservatives are generally not harmful in the used concentrations. Typically ethylmercurithioslicylate is used which breaks down in the body to ethylmercury. Ethylmercury is cleared from the body rather fast and should not be confused with more toxic variants (including methylmercury, which the form you hear about in wildlife and other tox studies).
  8. One thing to realize is that there is no career in "-insert research topic here." Rather there are jobs/careers that may (or may not) require knowledge in a certain area. I.e. you do not have a genetic engineer, but e.g. a process manager/analyst/project manager with relevant genetic (or other technical and non-technical) knowledge. As such it is is wrong to see college as a type of vocationa education but rather as a means to follow ones interest. That being said, the course that are relevant to your interest will vary from school to school. There is always a requirement for basic molecular genetics (regardless of system or application) and then some specialization afterward.
  9. Just be careful that the ambitious part is not only "sexy" element of your proposal. I.e. you may want to drum up the achievable goals. The reasons is that typically reviewers focus on the negatives (overall too ambitious) and easily dismiss things that may be perceived as minor outcomes. I got more success by selling the cool ambitious part as a bonus element whereas using the mainstream elements (which I found boring) as the "regular" outcome.
  10. The same thing happened in a University where I worked. A student put a laptop which did not shut down properly into a bag and left it unattended. After a while it started smoldering and releasing smoke. It is therefore prudent to check whether closing the lid actually put the laptop into sleep mode before putting it away.
  11. Good tips. A few things to add (and heavily echoing Arete): -be mindful of the type of reviewers you get. Scientists? Adminstrators? Adjust language accordingly. - always assume that reviewers are not experts on your field. Make it as broadly appealing as possible. - be only slightly ahead of the innovation curve. As Arete said, funding decisions are typically very conservative - be mindful of the mechanism. Howe much is the grant decision based on proposed research, vs quality of applicant? Is it a training grant, or do you have to demonstrate leadership? Are there outreach components? Do not underestimate the need to demonstrate abilities (i.e. more than just listing published papers) - do not make the reviewer work to make sense of your abstract. Tell them at the beginning why the project is great and use the rest just to bolster your argument. You either convince them in the first paragraphs or you don't - give yourself time to distance yourself from your writing in order to review it critically
  12. I did and and as I said, he was not elected, as this position was not He was appointed because the right-wing thought that they could use him to a) rally the workers and get them away from communists (remember, the fall of Russia is still in vivid memory and b) control him (among other reasons). You are also neglecting many things happening at that point, including parliamentary fragmentation, effective rule using emergency powers and other things. The appointment of the chancellor is not based on popular support. Though the economic situation did make the NSDAP, a deeply populist group highly attractive to workers as well as capitalists (due to their anti-communist stance). But to get back on track (although the whole bit is off-topic by now), installing Hitler was a power-political move driven by the republican corner. Now are there parallels to Hamas? Well in the broadest sense yes. There are economic issues, unrest and other similarities. But before I would do any judgement, I would have to read up much more on the power struggle there. While I digressed a bit I would like to note that your assertion was that I.e. that the people elected him (not true or at least only after he got power otherwise) and that WWI was the defining factor. Both of which are factually wrong. In discussing historical parallels it is extremely important to have the correct context and not override them with neat narratives that one may have built up.
  13. Well, the mitochondrial genome (in humans) is extremely limited and many functions relevant to mitochondria are encoded in the nucleus. That being said, there are quite a few transcriptome studies pertaining to exercise. A quick pubmed scan revealed that much is probably done on skeletal muscle functions.
  14. Also that is not what happened. Hitler was appointed (not elected) chancellor after a parliamentary crisis. He was neither that powerful nor popular initially, but he got significant support from the established parties when the Reichstag seriously fragmented (for various reasons). That put him into a position of power which later on helped him getting the combined president and chancellor position (though at that point it was barely an election anymore). Barely any parallels can be drawn to the Palestine issue.
  15. CharonY

    War in Ukraine

    I can only guess. However, considering that those that generally were against NATO were also more pro-Russian (i.e. East Ukraine) I would think that the ties to Russia are the reason that they were anti-NATO. It is important to remember that the Ukraine is in itself polarized in their stance towards NATO/EU and Russia, which is one of the reason for the initial protests.
  16. CharonY

    War in Ukraine

    Well, learning from history would require the knowledge of circumstance and context. It is certainly debatable whether there was actually a viable response to the Chamberlain's policy (especially with the lack of hindsight) and to some extent this is also the case here. It is relevant to note that entering NATO was and is also contentious from the Ukrainian side. Take a look at this Gallup poll http://www.gallup.com/poll/167927/crisis-ukrainians-likely-nato-threat.aspx.Before the crisis Ukraine was already deeply divided on NATO with the west leaning toward them (but still only 39% seeing them positively) whereas the east perceived them as threat (46%). Now the attitude has changed, but still with all the clashes, the support is around 40% as of June http://ukraine.setimes.com/en_GB/articles/uwi/features/2014/07/21/feature-01. Thus, it is likely that in March the referendum would not have passed. This is reflection of the complex situation as Ukraine and specifically Crimea has a significant pro-Russian population.
  17. Based on the German translation I would say it means a classification for a population of a specific region (or ethnicity). A synonym for demonym, so to speak. I.e. "American" would be an example of a gentilic.
  18. Isn't it pretty much the same word in English (i.e. gentilic)?
  19. The curriculum will vary from school to school, so it is hard to make a specific recommendation. The keywords are typically molecular biology, genetics, cell and/or microbio, biotech and variations thereof. You have to know that the things that you mentioned are rather basic tools rather than research directions per se. So you will have to develop interests around these topics (e.g. uses in plant biology, fermentation technologies etc.).
  20. These cocktails are not very specific nor is there a perfect combo that completely reduces protease activity (and does not cause downstream issues). For proteomic applications we found that working quickly on ice results in little or no detectable degradation. That being said, either of the mixes would cover the range of major protease classes.
  21. One could also argue that terrorism is a response to someone with a much bigger stick. Trying to discourage that by wielding an even bigger stick seems like the definition of insanity.
  22. This is just an assertion with little evidence. In fact, many generals and other military leaders were more than willing to continue. Depending on which scholar you ask, the atomic bomb provided various degrees of leverage for the emperor to call in a surrender (and even then there were mutinies). But most would agree that it was but one of the many aspects. And some would also argue that it was completely unnecessary after the invasion of the Soviets. As others are trying to explain, these events are massively complicated and simple cause-effect type of reasoning are almost always wrong.
  23. In addition to what Ophiolite said, the Japanese were hoping to broker a peace with the US via the Soviets. But the invasion of Manchuria and the destruction of the largest military unit that the Japanese still had shattered that hope. Considering that the previous firebombing that occurred over Japan were far more devastating than the atomic bombs, the narrative of atomic bombs as a direct route to peace is at best misleading (and a lousy bumpersticker to boot).
  24. I am not sure whether that is the intention of OP but sociopathy is generally regarded as a type of personality disorder. As is often the case, details and definitions can be fuzzy, but among the common factors named are often lack of empathy, poor impulse control and high self-confidence. The causes are under much discussion and appear to be very varied ranging from genetic influences to childhood upbringing. It will be almost impossible to elucidate defining elements. But based on that alone it is very unlikely that a singular aspect (such as games) will be the cause. In addition, one has to distinguish whether media act as triggers for sociopathic individuals in a given study/observation or whether it is a contributor in the development of psychopathy.
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