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Everything posted by jimmydasaint

  1. Wow. Well I have a PhD in Immunology and have forgotten more than you will ever know about Immunology (wink). I don't mean to be rude of course but did you not understand the clear explanation given? (wink again). In animal models, to be precise, mouse models, RhoC is over-expressed only in metastatic cells. That means that it seems to be essential in freeing up cells from the original parent tumour and allowing them to escape in the bloodstream to form secondary tumours. However, these are animal models of disease and there is no guarantee that there will be success in treating humans. Also, you were correct, the primary treatment will be surgical or chemotherapeutic but then, if caught early, the vaccine will be administered to "catch" cancer cells with over-expressed RhoC and for them to be destroyed by cytotoxic T cells. This is not a treatment for all cancers but, for a significant number of cancers, it represents real hope. Is it good news from an immunological point of view? Yes. Treatment with siRNA has already stopped significant metastasis apparently. If you want to invest money with these guys and your clients are rich, then go with the investment.
  2. You seem quite determined to do a PhD and I would never discourage you. Once you do well at your degree, I would apply to do a Masters in Science. In the UK, you get a small amount of funding for an MSc and you can taste what it is like to make an original contribution to Science. After that, if you are liked you can stay with your lab to do a PhD or move to another lab to start a new PhD. You have to keep your private life on hold and your supervisor starts off with a God-like status which soon deteriorates until you think he/she is a complete idiot by the time you finish your PhD. I don't know if that is a universal experience but it did seem quite common when I was a PhD student....
  3. You are so silly, with your formula for making beer - pouring root beer into a square glass.............................
  4. Tedor, my friend, get a job and make some money then hire a tutor in your own country who will help you study Physics. You may have to go to college in the evenings and work hard every day but your ambitions will help you through every day. Always keep them in your mind. Good luck.
  5. How human were H naledi? They buried their young, apparently, but there is no description of tools or other features of e.g. H habilis. Is it possible that it was a tribe with serious mutations that existed alongside H sapiens and have then become a footnote in history? There is a family of people who walk on all fours but are definitely human and have serious cognitive difficulties. Imagine if they decided to bury these people in a cave and it was discovered 400,000 years later. Is it possible to call them a distinct tribe of hominins? https://www.washingtonpost.com/news/morning-mix/wp/2014/07/17/the-family-that-walks-on-all-fours-and-why-they-cant-stand-up/?utm_term=.40b9a7e7b1dd
  6. Once again, thank you for stepping in and clarifying matters Function. I actually had a post-doctoral position to examine relationship of viral DNA and some cancers, but never saw the chemotherapy or radiotherapy side of the research - another danger of over-specialisation in research - everyone is seeing an elephant from a different point of view.
  7. I read an article today, which is relatively recent, but which touched me as a human. Humpbacked whales apparently save seals by fending off killer whales and it seems as if the behaviour is deliberate. I have copied parts of the article below and I would expect the Darwinian reply, but is there an alternative? First, excerpts from the article (bold emphasis is mine): https://www.newscientist.com/article/mg23230950-700-i-saw-humpback-whales-save-a-seal-from-death-by-killer-whale/ The scientist involved, Robert Pitman ( a marine ecologist) offered a Darwinian approach to the apparently altruistic behaviour of the humpbacked whales. Pitman believes that the behaviour is designed to chase off the killer whales from attacking humpbacked calves, which may be related to them genetically, and therefore they are acting in their overall self interest with the seal-saving being an offshoot to the self preservation of the humpbacked whale community. Now, is there an alternative explanation for why humpbacked whales actively save the seals? I would volunteer a couple of alternative explanations. Cetaceans might have an emotional sense of community and are preserving the lives of other animals in their community which are not food, or a threat. Alternatively, they are actively preventing the killer whales from feeding in their communities, thereby removing the threat of the killer whales feeding on humpbacked calves. However, do the humpbacked whales have a form of deductive logic similar to other limited numbers of species? Do others have opinions on this touching behaviour?
  8. You did not answer the question my friend. I asked which cancers involve damage to both strands of DNA? As prolonged X-rays in Western society would come from exposure to X-ray generators in hospitals why is this relevant to cancer therapy generally?
  9. Well, if progress involves working like a rat in a luxury trap and a primitive existence involves being more in tune with Nature, then it is definitely the primitive existence for me. I dream of simplicity - a caravan on a remote beach or a remote, simple existence where communities are smaller and actually care for each other.
  10. Thank you Function. I support what you say. Oncology references need to be recent - I must confess that I did not see the reference properly. However, I did search it up and I have copied the abstract here: http://www.nature.com/nature/journal/v412/n6847/full/412607a0.html The abstract refers to a protein, Ku made of two polypeptide chains bonded together that stabilises damaged DNA by encircling it, IIRC. The question must be asked from the writer of the OP, which cancers involve damage to both strands of DNA? How widespread are these? What is the possibility of using Ku as cancer treatment.
  11. You lucky sod. I am going grey everywhere and now estimate that I (at almost 55 years old) am now 80% grey. The worst thing is grey eyebrow and nose hairs. What do you do? Pluck? Leave them? Help.
  12. I think these were light and camera effects meant to show purity. It was a bit OTT. Nevertheless, I am a bit frightened of this stuff if I am honest: http://www.crossroad.to/articles2/006/freemasons.htm
  13. OK. thank you for that information. I should also explain that one of my friends is a lapsed Freemason and is not one of the evil guys I referred to in the OP. In fact, he is a decent bloke who I respect.
  14. I was very careful with my words. I said "appears to be Lucifer". the former Freemason wrote about it, not me. I am ignorant about Freemasonry, which degree are you?
  15. I saw a programme today on British television which showed the inside of the Grand Temple of Freemasonry - the United Grand Lodge of England. This was pure propaganda for the Freemasons and showed, at one point, light emanating from the genitalia of one of the Grand Masters of this movement. Freemasons were trying to show it as a charitable organisation which is involved with the improvement of the self. I don't believe them! In my opinion, it looks, from a perfunctory reading, that Freemasonry is a religion with religious rituals and is set up to organise mutual backscratching to the point of illegality. Freemasons that I have come across in the past have been some of the most evil men I have ever met. They talk semi religious nonsense to attract members and then organise bloodthirsty oaths to keep these unfortunate men in the fold of "The Craft". The ravings of one of their most revered leaders, Albert Pike, can be read here: http://www.freemasons-freemasonry.com/apikefr.html It looks as if Freemasonry is an alternative religion if you believe the writings of a former Freemason: http://www.cuttingedge.org/free004.html The God of this particular religion, if you rise high enough in the ranks appears to be Lucifer. http://www.cuttingedge.org/free004.html This is only my opinion and I am not trying to hurt members of the Forum who are Freemasons. However, I do feel that they have scored a significant victory in appearing on peak time TV with a sanitised version to attract new members. What do others know about these secretive people in "The Craft?"
  16. Teodor, I am a Biology teacher otherwise I would help you. You need a Physics specialist who can help you overcome problems in interpretation and understanding. II wish you the best of luck and hope that someone here can help to point you in the correct direction.
  17. Quick question. I look forward to seeing you back soon. Why don't you start posting on The Lounge where the standards for personal views and hypothesis are not as strict as some of the other Threads. Peace
  18. I like the quote by the Italian diplomat of the 19th century called Benso di Cavour who wrote something along the lines of: "Life is the shadow of a passing dream; the story is short and finite; the only immortal truth is love." I cannot conceive of a world where love does not exist and where all life is based upon scientific rationalism, which is IMO, what the OP is saying. But, is love outside the aegis of scientific investigation?
  19. Instead of giving a hungry geezer a few coins, I bought him a week's shopping - and I feel good!

    1. jimmydasaint


      Thank you guys. I'm no saint. I used to walk past these guys but have now lost my fear and engage them instead. I ask their name and why they are out on the streets. Most of the problems tend to be due to mental instability from my straw poll, but they tend to be OK people.

    2. Moontanman


      I have no shame in admitting it makes me feel good to help out others. I bought dinner and a hotel room for a woman and her child a awhile back. I ran into her at a local fast food place and she was trying to get them to let he work for some food. She had been brought down from several states away by her boyfriend and he abandoned her and her daughter to the streets a month later. I put her in tough with locals to get a bus ticket back to new jersey. She couldn't understand why I would he...

    3. jimmydasaint


      Love that Moontanman. I believe that the good we do comes back to us somehow and be sure that, when you need help, this act of charity will help you in turn. Great job man!

    4. Show next comments  12 more
  20. Wow! A superb ambition. I would start off finding free online courses which would improve your overall knowledge. This means college level Maths, Physics and maybe another Science. you do not have to be bright, just dedicated. Then, once you are in college, look up Khan Academy and other online sites to increase your knowledge. Once you have passed college, then apply to further online colleges - the Open University in the UK will cost you but you can work and study at the same time and your job is unimportant as long as it brings in money. http://www.open.ac.uk/courses/choose/ppcbrand?kwcampaign=bau%20england%20-%20brand%20phrase&keywordid=ggluk_open%20uni&mkwid=mc-ppc&gclid=CMiD6YTxqNMCFVcz0wodGVkIDA Before you do anything else, try this level at first: this is called P1 in the UK, the first Physics module taught in Yr 10. Follow up with P2 and P3. Then you have completed basic Physics in the UK to the level of a 16 year-old. This is to test your current knowledge. Good luck on your journey and never, ever, give up. https://www.youtube.com/watch?v=bR0boPq3v5Q PS: Ask this Forum if anybody is willing to teach you online for a small fee. you can work and then pay a small proportion of your money to this kind Science Forum person. Both would benefit.
  21. These hypotheses are interesting. So do scientists believe in an infinite Universe over a finite existence? Doesn't this matter then reduce down to subjective and personal belief then? This quantum gravity thingummy, isn't that Prof. Penrose's theory?
  22. qq - this is for you. we could chat by text or PM on this Forum or text on cellphone, if you like. I just want to say that there is ALWAYS hope and ALWAYS a way to get out of this mood. Tony Robbins is the real deal and this is not only my opinion. I have a link for him here: https://www.youtube.com/watch?v=GqjWfPWfl5g It's 2 am in the UK dude, I m going to sleep. Take care, you are of great worth and, once you are out of this state, you can help others. All the best to you brother/sister/whatever.
  23. qq - I have not read about HBI but many of Tony Robbins' lectures are on youtube and I have been watching some of these programmes recently. I don't want to get into detail at present about how depression has impacted my life, but I am here if you PM me and, if you need me, I will give you my cellphone no. just to talk and for me to listen - I am an excellent listener. Peace.
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