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Everything posted by jimmydasaint

  1. I have a "Best of Floyd" CD. Loved every track. Great for de-stressing. Hope you are well mate.
  2. You are right mate. But I always gave everything I did 100%. As a scientist and as teacher of science. I think I bolloxed up the parent part as a consequence. I need a few minutes "me" time. I fo like the way you slipped in a Pink Floyd lyric (is it Floyd or Genesis?) My main interest is Science. I guess it sounds corny but I still get excited over new or inspiring science. Love the puns. I do listen to zany comedy such as Ross Noble on you tube and it keeps me happy but life is complicated and hard - maybe it was never meant to be easy - and I do struggle but keep going. I like your regimented attitude. I am 5ft 4in and 75 kg. My diet is one toast and decaff coffee for breakfast. Two salad sandwiches for lunch. Pasta with chicken or rice with chicken as a main meal. One bar of chocolate and one caffeinated tea per day and one bag of crisps. This has been my daily regime for 18 years. I didn't get any rel exercise for 2 years and this messed me up. There is no excuse for not doing push-ups. I agree. You know what, I hate stirring up things. I normally have a clam and phlegmatic personality - it takes a lot to stir me up. Injustice and senseless killing of other members of our planet really piss me off though. We are here to work with Nature and not to conquer. Humans have the wrong attitude and we will pay for that as a species. Wow! That felt good. That is beautiful but you are talking to a Scotsman and when it comes to flight or fight - there is no running unfortunately. Scots people love a good argument, it's in our nature unfortunately.
  3. I had a heart attack about eight weeks ago. There was an occlusion (blockage) in one of the arteries of the heart which supplied oxygen and nutrients to the heart muscle and I crumbled. After an operation which was apparently successful, I have been told by doctors, colleagues, relatives and friends to reduce stress. However, as a Science teacher in 21st century England, life is stressful. As a parent, it is stressful. My complicated personal life is stressful. How on earth can I relieve the stress using a natural method? I have heard about breathing techniques etc... but how would logical, rational beings on the Forum cope in a natural, pill-free way to relieve stress? (I hate pills). Any advice welcomed.
  4. As a former researcher who labelled proteins with 125-I IIRC, only an idiot would leave any residual radio-isotope behind after a procedure. Normally the room would be clearly marked and a lead-lined area used with lab bench lining in case of accidental drops of isotope. A Geiger Muller counter was always pointed at the area of use as an additional warning and a biohazards/radioactive bin nearby for disposables. Following use, the material was encased in a lead container and the bench wiped down with an industrial detergent. The bench lining/coat (like a plastic coated paper) would then be removed and disposed off in a biohazard/radiation bag and the area monitored with the GM counter following the procedure. These, in my opinion, are normal precautions. I never entered a room which had contaminants from a previous researcher. We were aware of safety considerations for others. As StringyJ has mentioned, all non-nuclear industry isotopes have a short half life. You were probably safer to work there than a bacterially and virally contaminated library. Ain't it ironic?
  5. What level of education are you jewel? K13? or A2 level ? That would influence the depth of your project and the depth of your responses.
  6. I think you should ask the Mods to post this in the "Homework" thread. and then refer to this: http://highered.mheducation.com/sites/0072507470/student_view0/chapter3/animation__mrna_synthesis__transcription___quiz_1_.html It is explained simply. If you don't get it, someone will help you out.
  7. That was brilliant! Please give me instructions, preferably in bullet points. Wonderful and can be tweaked. Both worked on my computer perfectly. Well done. Please share your method.
  8. This is so damn clever. If I read it correctly, CRISPR is a tool to edit DNA in a specific way. CRISPR has two parts to it: a cutting tool called Cas9 and a guide RNA. The RNA guide strand which is complementay to specific DNA binds to it. As it does so, the Cas9 bit of CRISPR cuts the DNA. Usual gene editing can add or delete a piece of DNA if required. This is a mutation created specifically in a specific part of the DNA. In this case, the toolkit is used so that the very DNA of the cell which made the guide RNA is cut by CRISPR but only if a certain molecule is present, e.g. like a molecule present during inflammation. As the DNA is cut by the CRISPR, a deletion is made (frameshift?) which then changes the sequence of the guide RNA. The CRISPR then travels back to the DNA with a changed sequence and cuts it out. the longer the stimulus/inflammation etc... molecule is present, the more mutations that accumulate in the DNA that codes for the guide RNA. Others can correct my interpretation, but, if what I have written is correct, this is the most exciting thing I have read in years. Great find DrmDoc! (Caveat - if I have ballsed up the explanation, please correct me) http://news.mit.edu/2016/recording-analog-memories-human-cells-0818?ncid=txtlnkusaolp00000618 Images show DNA being made into complementary RNA and then an image on how CRISPR works.
  9. Wow! i have just read the discussion above. I won't add my tuppence worth but I would advise the writer of the OP to read the following and, if there are any issues, to get back to the wise and compassionate staff on Sfn. http://www.wisegeek.org/what-is-hydrostatic-pressure.htm
  10. Thank you. I take it that I need to use a disk with the animation on it. Is there any way to take an animation off a website and then embed it into a post for education purposes?
  11. Thank you for that heads up. Is it difficult to do given my limited computer knowledge?
  12. Any clues. I can just about login to Science Forum and have a reasonable knowledge of Word processing and Excel ( enough knowledge to make a Table in Word and change a cell value in Excel). So, my knowledge of using code is very limited. I would really like to present something like this in a post as an animation: http://highered.mheducation.com/sites/0072495855/student_view0/chapter14/animation__transmission_across_a_synapse.html
  13. I think a good animation or diagram is better than a hundred words: http://highered.mheducation.com/sites/0072495855/student_view0/chapter14/animation__transmission_across_a_synapse.html Come back after watching it and ask for further help if necessary.
  14. Sorry about this but your citation referenced a person who did not write was stated. Do you have a different citation please? I looked up the original 1953 paper and must have missed all these facts. Aebersold only mentioned applications of radioisotopic iodine etc...
  15. Pretty spiritual stuff here iNow. That is a nice quote from the author. Believe it or not, this was the thing that absolutely hooked me into biology as a teenager. It was the recycling of all matter throughout the biosphere. It was stunning and awesome. On a general note, are there estimates of how many atoms we have that are recycled from humans of old, or about how quickly the body recycles its cells? I seem to remember a figure of 7 years to recycle all body cells (except for brain cells?)?
  16. The actual cells are different IIRC. I will return with a citation if I find it. IIRC, maternal cells enter the embryo during pregnancy and embryonic cells enter the mother and, in certain cases in animals, had a protective effect. Awesome and beautiful. However, and this also needs citations, some forms of electromagnetic radiation damage DNA in germ cells. Keep the ideas coming and keep posting them in Speculations. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633676/ I cannot verify the scientific accuracy of the following. I can only present it: Right, I really have to sleep now.
  17. Please read the quote, it is actually about stripping hydrogen atoms off DNA, not breaking phosphodiester bonds: https://www.scienced...60518181301.htm I am also including an animation on DNA. Look at the complications of the bonds: http://www.johnkyrk.com/DNAanatomy.html
  18. http://www.ncbi.nlm.nih.gov/pubmed/20663262 2. The DNA of the germ cells also receive lesions and ages, but in meiosis I and meiosis II and become zygote and eventually baby have an important step that fixes these lesions with a perfect repair, not the usual partial repair we have in our cells, it could also be that the genes are shuffled around in meiosis I and meiosis II that fixes the damage. Why do I come to this conclusion? Because the baby is not of age 29 years old when it's born or the baby ages faster with a damaged DNA, the baby's DNA has to be perfect with no damages when it's born. I don't know about meiotic repair, you would have to cite something to prove your point. Nevertheless, repair mechanisms occur to re-age chromatin in germ cells: http://www.hindawi.com/journals/bmri/2014/925121/ Now for the conclusions for speculations 1 and 2: 1. For speculation 1, if we can obtain an undamaged DNA from the germ cells then we know which part of the DNA is damaged in other cells of the body and attempt to replace them with the undamaged one assuming all the DNA in our body are the same but only differs with gene expression. 2. For speculation 2, we need to identify the step that does a perfect repair to the DNA and duplicate that process for all the cells in our body. Keep in mind that in order to change the DNA in our body we need a nanomachine, crispr also works but we need 100% accuracy. I haven't found a DNA nanomachine capable of altering DNA. I thought that different humans would receive different damage depending on exposure to different ROS, different chemicals (mutagenesis), different diet, different ages (older people accumulating more hypothesised damage, different genders, different professions etc... I think you would struggle to ask 100 women to donate their ova and for your research to be performed unless the legislative authorities allow experiments on human eggs. There is a serious ethical issue here, in my opinion, which religious groups would jump upon. As for nanomachines, I don't imagine that nanoscience has yet reached this stage. P.S. I feel that the DNA damage theory is a bit outdated, everyone follow a set age normally of 100+- years of age. You don't live longer or shorter because of damages done to your DNA For a short chart: 1. parent undamaged DNA + parent undamaged DNA -> baby undamaged DNA 2. perfect repair(parent damaged DNA) + perfect repair(parent damaged DNA) -> baby undamaged DNA How many sperm would be repaired given that there are 300 million approx. released per ejaculation? The idea is good and you posted in the correct place. But, it needs a bit more background research about what is possible and what is not yet in the vista of scientific capability.
  19. https://www.sciencedaily.com/releases/2006/05/060518181301.htm The article is about computer chips. If you have a personal theory fredreload, why not state it clearly. This is the proper forum for speculations and psudoscience.
  20. Another couple of worrying statistics: 1. black women are more likely to die in childbirth than white women, regardless of demographic factor matches between both races. 2. As much as one third of the deaths were preventable. In the richest nation in the world, people are dying from having poor healthcare, or poor healthcare education - the purview of public healthcare bodies. My worry is that propaganda and political shenanigans have started in the UK to privatise and polarise healthcare in this country by picking on the conditions for junior doctors (this makes my blood boil, but I don't want to sideline your thread).
  21. Of course I hope it goes smoothly and that you are fit and well again. But, if you have time and you could ask the surgeon to put a photograph on top of the lights just in case . But in reality, my very best wishes for the operation and hope that you will come back at a time that 10 extrasolar Earth-like planets are discovered, just to cheer you up.
  22. With respect, your OP is what I answered. That subject is not closed unless you comment on the paper extract that I gave you and then we come to a conclusion. If you are creating another question, why not start a new thread?
  23. I don't understand why this is posted in the "speculations" thread. Nevertheless, the restoration of telomere length is a poorly understood process, but this seems to occur at an early developmental stage, not during meiosis but possibly during post-fertilisation mitosis, if I have read this paper correctly: I gave you a fairly long quote without editing by me: http://www.nature.com/ncb/journal/v9/n12/full/ncb1664.html
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