Ok, these structures may be huge, but it wouldn't be the same as living out in the open with wide open spaces. Modern cities are restricting but there are still open spaces, such as parks. Closed-space psychology is interesting. A notable case of this is the miners in Chile, and after a few days some of the miners got depressed. I think, no matter how big the structure is, living in an enclosed space would be horrible, for the first generation at least. It would be intresting to see the second generation and the ones after, and see how different they would be having lived in an enclosed space for their whle life.
Of course, people could be let out of the structure, but if your thousands of storeys up, it would be pretty hard.