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What do you think is the most likely explanation for the Fermi paradox?

Title says all.

The human brain is sharpened for three-dimensional space, but in our hypothetical scenario, even the brain itself will be five-dimensional. If you start with organic matter, amino acids are useful precisely because they form certain three-dimensional structures. Then all the tricks immediately become available, such as passing through locked doors, mirroring, etc. This is when the heart is on the right, and all L-amino acids change to D-. If there is a transparent sheet of text on the table, then turning it over will give you a mirrored text. And if the sheet is obliged to remain in the plane of the table, then this effect cannot be achieved in any way. Adding extra dimensions to 3D space is the same story. Specular reflection turns out to be a special case of rotation

Wormholes have never been observed directly or indirectly, but they "exist" in a mathematical sense when they arise in the solutions of the gravitational field equations underlying Einstein's theory of general relativity. This means that we can split the universe into many parts and then use mathematical equations to describe how those parts fit together.

3D printing is a fast and cheap rocket production system. A lot of companies use 3D printing to create small rocket components for assembly. So a huge mass of parts turns into an ordered device - a booster rocket like Skylark-L.  3D printing reduces development and part optimization costs. By applying 3D printing to the rockets the humanity could produce one rocket every 60 days. Agree - this is much less than the 12-18 months that traditional production methods offer us. 

The collision of Andromeda and the Milky Way has already begun. The reason the collision occurs several billion years ahead of schedule is because the Andromeda galaxy is much larger than it appears. The bright stellar disk of this galaxy is about 120,000 light-years across, slightly larger than the Milky Way.

There are no reasons against Mars landing in 2024. I believe he surely reaches 

The Perseverance rover was able to convert carbon dioxide from the Red Planet's atmosphere into oxygen using the MOXIE instrument. The experimental apparatus produced 5.4 g of oxygen, which is enough for 10 minutes of breathing.

I guess after China's success in the Moon landing and probe taking lots of space company all over the world begins the exploration which surely could lead humanity to space colonization. In the UK, for example, it has begun - there is a company represents a new breed of private rocket companies developing the next generation of launch vehicles for the burgeoning small satellite market.

According to chemists, a lot of chances are needed for protein to form in space. In order for hemolithin to form naturally in the found configuration, glycine in cosmic dust grains is first required. After that, heating by molecular clouds could lead to the fact that the glycine units began to bind into polymer chains, which at some point evolved into fully formed proteins.

Among the 24 candidates for a "super-habitable" planet, none of them meet all the criteria. Planets do not have to be very old to be habitable, otherwise they will exhaust geothermal heat and lose their protective geomagnetic fields. The earth is about 4.5 billion years old, but researchers argue that the optimal place for life is on a planet that is between 5 and 8 billion years old.

Not all matter is drawn into the hole. It forms the so-called accretion disk - a bright cloud of gas and other substances. It is because of this disk that the galaxies glow so brightly - it glows brighter than 300 trillion suns. It is also the cause of turbulence. It is not yet completely clear whether all the gas pushed outward will leave the galaxy, or whether it will be swallowed up by a black hole.

The closest known approach to Apophis will occur on April 13, 2029, when the asteroid is about 31,000 kilometers from the Earth's surface. Distance, astronomically, a hair's breadth, five times the radius of the Earth, ten times closer than the Moon, and even closer than some artificial satellites.

No one hasn't posted the news - so I'll try. NASA has already selected astronauts for Artemis mission. In the final stage of selection for the Artemis mission, NASA selected the 18 best candidates who are already members of the astronaut team https://spaceflightnow.com/2020/12/09/nasa-names-18-astronauts-for-artemis-moon-missions/

The probe has already set two new records - for the speed of movement of the man-made spacecraft 393 044 km / h and for temperature - the protective screen, under which all scientific instruments are located, heated up to 612 ° С, while its interior and scientific equipment remained at the temperature about 30 ° C.

Dr. Yamagishi and his team came to this conclusion by placing dried Deinococcus colonies on display panels outside the ISS. Samples of various thicknesses were exposed to the space environment for one, two, or three years, and then tested for their survival. Three years later, the researchers found that all colonies larger than 0.5 mm had partially survived in space. Observations show that although the bacteria on the surface of the aggregate died, it created a protective layer for the bacteria underneath, ensuring the survival of the colony. Using survival data after one, two, and three years of exposure, the researchers calculated that a granule greater than 0.5 mm thick could live 15 to 45 years on the ISS, thus proving the possibility of natural interplanetary transfer of microbial life that would otherwise called panspermia.

The main influence is on technical systems. As a result, failures in the electric power system or equipment generally fail. This is most relevant for northern and southern countries. So in 1989, the local power grid in Quebec went out of order, and, accordingly, the entire population of Quebec was without electricity for 9 hours. The next largest loss is the impact on aviation associated with the recently opened transpolar routes that fly passengers from Europe to the United States. When a magnetic storm, a solar flare, and particle ejection occurs, an increase in the radiation background occurs there, moreover, there is also an interruption in radio communications, which is especially dangerous from the point of view of air traffic control. Therefore, planes either stand until this is over (usually several hours), or are forced to fly along a long route and, accordingly, spend more fuel. In both cases, airlines incur losses. The third impact relates to users of navigation satellite systems such as GPS.

What do astronomers think they’ll capture with the James Webb telescope?

NASA aims to reach Mars by 2035, but I don't believe NASA, I guess SpaceX will be the first to send the first human there. 

The water persists both on the dark and light side so the new settlement can be built on whenever we want.