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There is not a huge difference as far as lab strains go. Due to the fairly permissive situation in the lab the strains are not competitive. What you would need to do is recreate a bacterial community for almost any possible surface and reservoir. How would that happen? Unless you spread AB-sensitive pathogens around (and get arrested for bioterrorism). Sensitivity is not a particular trait that spreads around. Nope, everywhere where you can find antibiotics you select for those bugs. These include wastewater, manure and basically everywhere they end up, ranging from soil to water sources. This is why the current situation has become so dire. It again implies something that is competitive. In a given environment. Unless you want to smear everything with a biofilm, which again is a horrible idea. If only because you cannot prevent the strains put out not to acquire or become resistant. Look, you need to know the basics of resistances. Some of which require a simple point mutation. You cannot breed that away, bacteria are not cattle. Even if we only think about more complex systems, such as efflux pumps, what is going to happen is that the existing traits will spread including through your artificial population (assuming they manage to persist a significant time frame), creating a brand new reservoir of resistances. It is simply a bad and unrealistic idea.

Okay, several things. Cleaning doesn't remove everything. In the fungal world there are species that can colonise hospital surfaces and persist for up to 2 weeks without moisture, even after cleaning (see: Candida auris). Some strains make biofilms, which are resistant to disinfectants. Resistance to cleaning products may also be an acquired trait. Point being, you're not going to remove all of it and good luck stopping resistant strains from colonising patients just because they already have an infection from something else. Moreover, once you've cleared the infection of your susceptible strain, do you honestly think that the other pathogens hanging around won't infect? In reality, you've left them a lovely little niche ripe for abuse. And finally, resistance can be an acquired trait. This can happen during treatment. I'm going to switch back to fungi here because that's what I know, but there are cases where treatment with drugs that were initially effective stopped working before the course was finished because the fungi (Candida auris again) became resistant. I would seriously question any ethics board that let you test this in animals / humans.

You're missing the point. If there are resistant strains about, and you are treating infection of the sensitive strain with antibiotics, the resistant strain will quickly outcompete the sensitive strains. I also mentioned that acquired resistance exists. My work is in antifungals, but bacteria are similar in the sense that populations that are not initially resistant can become resistant over time through exposure. As CharonY said, you don't appear to know much about resistance mechanisms and how it can spread. I would suggest reading up on it and then revisiting your idea to understand why it won't work, bioterrorism aspects notwithstanding.

! Moderator Note In which case, this is closed.

Sensei : only 7722 will make it ! Which is also double of 3861

! Moderator Note Thread closed then.

! Moderator Note Sorry. You have been told multiple times to post your explanations here. Thread closed. Also, stuff like this belongs in Speculations. Please re-read the rules you agreed to when you signed up.