thankududes
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Hey, if I start a titration of Histidine at the pKa of the N-terminus (pH of 9.1) with HCl, where would the first equivalence point be? I was thinking that the 1st equivalence point would be between 9.1 and 6.0 (pI) however mols of buffer would not equal mols of acid until the pka of 6.0 is reached. On the titration curve I must label where this equivalence point is but I have never started a titration at a pka before, can someone please help? thank you!
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Amino acid nasty titration question
thankududes posted a topic in Biochemistry and Molecular Biology
Hey, if I start a titration of Histidine at the pKa of the N-terminus (pH of 9.1) with HCl, where would the first equivalence point be? I was thinking that the 1st equivalence point would be between 9.1 and 6.0 (pI) however mols of acid would not equal mols of base until the pka of 6.0 is reached. On the titration curve I must label where this equivalence point is but I have never started a titration at a pka before, can someone please help? thank you!