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p-Nitroacetanilide synthesis

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#1 Bioc



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Posted 19 June 2012 - 03:13 AM

Hi, I was wondering why the nitration of acetanilide requires the use of sulfuric acid AND acetic acid. I understand that the acid medium is used to solubilize the acetanilide, so why is concentrated sulfuric acid alone not enough? On a side note, the sulfonitric solution is prepared in another tube and later added to the acetanilide mix.

As far as I know, the use of glacial acetic acid is to keep a low percentage of water, and thus, prevent hydrolysis, but this can be achieved using only the concentrated sulfuric acid.

So, why is (glacial) acetic acid needed?
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