[quote name='Halucigenia' timestamp='1328638528' post='656707']
Uh oh, I thought it might be a mistake to interject in this thread. Quite, that's why the selfish gene is such a good metaphor.
Mike's reply:
Two opening points: I confirm that I, too, although recognising that genes are in fact mindless specks of DNA, nonetheless find it extremely helpful to envision them as being selfishly obsessed by their individual replication. I also affirm that where characteristics defined by two separate genes act to complement each other when expressed in an organism, the genes can, again, metaphorically, be seen as cooperating to mutual benefit. However, to use a sporting analogy, that cooperation is as conditional as it is between players in a professional sports team: if Player A is dropped because Substitute (= rival allele) B is deemed better, Player C will cooperate just as enthusiastically with the replacement as he did with the original. With both the player and the gene, the sole driver is a wish to be in a side/organism that's winning. Thus even cooperation is selfish.
As for language, my interests spread very widely and include creative writing. Sadly, therefore, I lack the polished patois of the specialised genetic theorist. I hope I will be forgiven!
Regarding sexual selection, I still think that had it a choice and could control its own environment – which patently it does not and cannot – a rank and file selfish gene would elect for the certainties of asexual reproduction in a very stable environment rather than the lottery of sexual reproduction in an unstable one.The one exception to this would be the genes involved in defining every facet of the processes of sexual selection who would be put out of business were a species to revert.
That said, both sexual reproduction and consciousnessare very much side issues to the debate I have sought to initiate and, although having introduced them myself, I would now sooner put them to one side or deal with them as separate topics if anyone is interested in setting this up.
As the heading "Selfish genes and self-destructive behaviours" makes clear, my interest here is in trying to explain what has been described as one of the thorniest of the outstanding evolutionary puzzles:
"Why has natural selection equipped us with biological and psychological mechanisms which are capable of increasing our susceptibility to diseases that make us likely to die prematurely." ("The Sickening Mind", PaulMartin, 1997, p.306). [In the US, it's "The Healing Mind", vive la difference!!!].
The psychological component of the processes to which Martin refers is major depressive illness , of which he says this:
"The sheer universality of depression – or, at least,the capacity to become depressed – suggests that its underlying biological mechanisms are a basic feature of human nature. So why has natural selection equipped us with the capacity for something as disabling as depression?" p.304.
The biological component to which he refers, is the now overwhelming evidence – detailed in his book and my paper – that depression is the royal road to a whole slew of physical ills that would have taken individuals in the natural world very rapidly out of the picture (sorry!).
The easiest way of comprehending the answer I am offering is to put "Family stigma, sexual selection and the evolutionary origins of severe depression's physiological consequences" into Google and then read my recently published paper which has passed through the peer review process.
Suffice it to say here that I have come to believe that the answer to Martin's question lies in the process of sexual selection. If, as stock-breeders and insurance companies definitely do, individuals selecting sexual partners (not just humans) use family members as a valuable guide to a potential mate's underlying genetic worth, what is routinely called "the genetic arms race", would call for a counter-strategy. And in the ruthless world of naturalselection, the most effective strategy would be to eliminate any individual whose own gene through-put was likely to be significantly exceeded by the qualitative and quantitative negative impact he or she is likely to have on the aggregated gene through-putof close kin, merely by existing.
Using siblicide or infanticide in the context of an individual who – for all its limitations – had evolved to fight like hell for its continued existence would be a very risky strategy as it might well severely damage kin in defending itself. The obvious solution – or so it seems to me –is the use of depression, to employ a very colourful (sorry!!) analogy, as a stun gun. Once the gene-based linkage between that and the host of physiological consequences Martin details (many of which are also to be found in my paper) was made, from the point of view of natural selection and inclusive fitness, it was all plain sailing (sorry, again!).
I fully acknowledge that the implications are appalling, but with major depressive episodes already high up the World Health Organisation's list of diseases causing most impairment to human existence and rising higher,I believe that it better that we understand what is going on.
This post has been edited by Mike Waller: 8 February 2012 - 12:47 PM