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Synthesis Help Rate Topic: -----

#1 7 April 2009 - 02:43 PM blazinfury 


Quark
I need to synthesize, Phensuximide. The molecule is attached below. I need to begin with a benzaldehyde. Any advice? Thanks.

Attached image(s)

  • Attached Image: synth.png

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#2 7 April 2009 - 10:59 PM Kaeroll 


Baryon
Found a decent (at first glance... I emphasise the brevity of my search here) looking paper on the synthesis of derivatives of your compound. The reference is Miller et al, J Am Chem Soc 1951, 73 (12), pp5608-5610.

If you're looking for a retrosynthetic analysis I can't help you - I'm rustier than I care to admit with some of this chemistry.
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#3 8 April 2009 - 10:22 PM UC 


ydoaPs just lost the game
Big hint: start with a wittig reaction to make styrene. SN2 will be important later on. Think cyanide.

This post has been edited by UC: 8 April 2009 - 10:44 PM

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