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ACTIVATION OF APOPTOSIS AND BAK AND BAX PROTEIN COMPLEXES


Cristian Ramos

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23 hours ago, Cristian Ramos said:

 

23 hours ago, Cristian Ramos said:

 

WHICH PAPER PERFORMS THE DOMAIN OF PROTEINAS BH3 ABOUT THE BAX AND BAK COMPLEX FOR THE ACTIVATION OF THE APOPTOSIS PROCESS.

AND IF THERE IS NO CATIVATION OF THESE PROTEINS THAT WILL HAPPEN, DEVELOPMENT WILL BE UNCONTROLLED. ?


 

 

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29 minutes ago, Endy0816 said:

Not clear what you are asking.

There is necrosis when cell death happens in an unregulated fashion.

but if there is no activation of these protein complexes that activate apoptosis or cell death, 
it is carried out: saturation of diseased cells, mutations .. etc or as apoptosis is regulated
Edited by Cristian Ramos
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The properties of Bcl-2 are so relevant and diverse that they can decide the outcome of a cell, either by apoptosis, necrosis or autophagy. However, this ability, if poorly regulated, can allow altered cells to survive and give rise to strains with these characteristics and additionally acquire others.

DNA alterations cause the suppression of proapoptotic subfamilies, the most important, the Bax complex and the synchronous suppression of p53, which causes the first control point to miss serious gene errors and that there are no proteins that annul these cells sick.

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on the other hand, the mitochondrial apoptotic life is induced as a response to cellular stress and results in the activation of pro-apoptotic BH3 proteins only 
the BAX and BAK are two encoded nuclear proteins present in the higher eukaryotes that are capable of forming the outer motocondrial membrane to measure cell 
death by apoptosis, is there in this mitochondrial outer layer some factor or regulation that protects it and does not allow the entrance of these two nuclear 
proteins and therefore avoids the process of apoptosis?
Edited by Cristian Ramos
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