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Vaccination: Partial cell lysate vs. specific proteins


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Vaccinations can be as low as 40% effectiveness and as high as 95%. 

In thinking of ways to raise the efficiency of vaccines with < 50% prevention, wouldn't it be more advantageous to use part of a whole cell lysate (taking out the bad stuff)

than using a handful of proteins that produce immunogenicity? At least this way, you're catching all the small interactions with cell components/ proteins that you would miss with just using a

surface protein or flagellin. Sure, you may raise the immune reaction a bit, and produce an elevated fever, but this would be common place in time. If you get a colonoscopy (very short procedure)

you're out of commission for the whole day. 

 

your thoughts?

 

~EE 

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From what I know it's not always possible making an attenuated or inactive version for a vaccine especially for bacteria that has a more complex structure. The chances for side reactions on a subunit vaccine are also lower. When using a subunit vaccine they also use inmunostimulatory agents for a proper inmunogenic reaction.

There's an interesting article I found. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883798/

 

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