estimating recombination frequency with distance?

[dgaita]

Hi everyone - I'm doing some work in psychiatry genetics and am looking for a way to estimate the likelihood that two genes are linked. I understand that basic concept that experimental measurement of recombination frequency is used to estimate the distance between two genes. Theoretically then, one should be able to use the distance between two genes, when it is known, to estimate the recombination frequency. Does anyone know mathematically how this would be done?

 

To reword this in my specific case, I'd like to estimate the recombination frequency of two genes on chromosome 6 (171 million base pairs) which are known to be ~6 million base pairs apart.

 

Thanks for your help.

 

-DG